An EDNA system would put advanced biotechnology and IT into every cell of our bodies and enable interfacing to almost every aspect of our current biology, and also provide a means to edit, replace, enhance, mediate and control almost every aspect of it. It will in due course give us the full capability to change not only the nature of humanity, but all the rest of nature. The first stages could make us transhuman, the later stages could make us full cybernetic hybrids with AI, and the third stages could make us post-human, with most of the biological DNA, proteins, organelles and other cellular inclusions and processes given by nature fully edited and interfaced to our future desires, and the system could be applied across as much of nature as we wish. It is therefore not only a tool for transhumanism, but for transbiology.