The play begins with Deianeira, wife of the absent hero Heracles, expressing her fears about his long absence and possible infidelity. Her anxieties are confirmed when she learns that Heracles has sacked a city to claim the young princess Iole as his concubine. Desperate to regain his love, Deianeira sends Heracles a robe anointed with what she believes is a love charm—a potion given to her years earlier by the dying centaur Nessus, who deceitfully claimed it would ensure Heracles’ fidelity. But unbeknownst to her, the potion is actually a deadly poison that sears Heracles’ flesh, subjecting him to unbearable agony.
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