Part I focuses on DEA applications in business, including healthcare, supply chain management, and governmental organizations. Part II delves into the application of DEA in banking and finance, providing valuable insights into the efficiency and performance of financial institutions. Part III explores DEA's diverse applications in sustainability, addressing topics such as sustainability indicators, resource mobilization, food production, and farming. In essence, this Handbook stands as an invaluable reference work for stakeholders seeking to optimize organizational efficiency and performance across a variety of sectors.