RNA-Binding Proteins Part B

David Christianson · Karen N. Allen · Subashchandrabose Chinnathambi

Mar 2027 · Methods in Enzymology Book 744 · Academic Press

Ebook

258

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Eligible

This book will become available on March 1, 2027. You will not be charged until it is released.

About this ebook

This volume brings together a comprehensive collection of contemporary methods and applications for investigating RNA biology, RNA–protein interactions, RNA-binding proteins (RBPs), non-coding RNAs, RNA processing, phase separation, ribosome biogenesis, and RNA-based regulation and therapeutics. As Volume 744 of the Methods in Enzymology series, it emphasizes the integration of methodological innovation with biological applications, providing researchers with practical approaches to understand how RNA–protein interactions regulate RNA stability, localization, translation, processing, packaging, and cellular function. A major strength of the volume is its coverage of emerging and rapidly developing areas of RNA research, including RNA–protein condensates and phase separation, circular RNAs, RNA-binding domains, RNA editing, miRNA trafficking, and RNA-based therapeutics. The chapters provide complementary perspectives spanning computational prediction, molecular and cellular biology, structural biology, advanced imaging, genetics, proteomics, and disease-relevant cellular models.Collectively, the volume serves as a multidisciplinary methodological resource for researchers investigating RNA, RNA-binding proteins, and RNA-regulated cellular processes. By bridging computational, biochemical, structural, and cellular approaches, it provides a valuable framework for understanding the complex mechanisms governing RNA function and RNA–protein interactions and supports the development of new strategies for studying RNA biology in health and disease. - Computational Prediction and Structural Analysis of RNA–Protein Interactions - RNA–Protein Interactions and RNA Cargo Trafficking - RNA Processing, Non-Coding RNAs, and RNA Regulation - miRNA Biology and RNA Packaging - RNA–Protein Condensates and Phase Separation - Features high-impact reviews exploring the latest discoveries and methodologies in RNA-binding protein research

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About the author

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering

Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.

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