Cell Death Part A

Lorenzo Galluzzi · Manuel Beltrán Visiedo · Emma Guilbaud · Ruth Soler-Agesta

2026년 4월 · Methods in Cell Biology 205권 · Academic Press

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Cell Death, Part A, Volume 205 explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. Chapters in this new release include Methodologies for Monitoring Alkaliptosis in Cancer Cells, Protein-complementation assay and DISC analysis, Detecting phosphorylated MLKL in murine tissues, Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis), Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds, CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia, and much more.Additional chapters cover Cell death assays for the detection of acute kidney tubular necrosis, Methods of cell death imaging by Incucyte and similar platforms, Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis, Monitoring inflammasome activation by analyzing ASC specks and oligomerization, LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models), Evaluating protease activation and inactivation of gasdermin cell death effectors, and Measurement of plasma membrane rupture via confocal microscopy. - Explains the underlying molecular and biochemical mechanisms driving various cell death processes - Presents state-of-the-art experimental techniques and assays for detecting and studying cell death in vitro and in vivo - Discusses the therapeutic potential of targeting cell death pathways, including drug development, resistance mechanisms, and clinical applications

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Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.