Fundamentals of Brain Organoids for Neurological Diseases

Balachandar Vellingiri · Mahalaxmi Balachandar

Oct 2025 · Academic Press

Ebook

400

Pages

Eligible

About this ebook

Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms. - Presents the steps involved in the generation of brain organoids from HiPSCs onwards - Summarizes the importance of organoids in understanding various neurodevelopmental disorders - Reviews the ongoing clinical trials using brain organoids - Discusses ethical considerations when conducting organoid research

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About the author

Dr. Balachandar Vellingiri currently is investigating various neurological diseases and developing human induced pluripotent stem cells (HiPSCs). Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. His expertise is on several techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases.

Dr. Mahalaxmi Balachandar is currently an Assistant Professor in the Department of Community Medicine and Health, School of Health Sciences, Central University of Punjab, Punjab currently involved in handling neurological disorder patients and conducting genetic and epigenetic studies. Her expertise is in handling bone marrow derived mesenchymal stem cells (BM-MSCs) as a promising therapeutic agent for LHON disease.

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