Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression
James Greenblatt, MD · Bill Gottlieb, CPHC
Jan 2026 · Penguin Random House Audio · Narrated by Stephen R. Thorne
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11 hr 35 min
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A groundbreaking personalized model for psychiatric treatment of depression that helps readers identify their body's unique interplay of nutritional factors, biochemistry, lifestyle and genetics for effective and lasting care.
“In this timely and transformative book, Dr. James Greenblatt boldly dismantles the outdated paradigm that seeks only to suppress symptoms with one-size-fits-all medications.”—David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain
“If you or someone you love struggles with depression, this book is essential reading.”—Mark Hyman, MD, #1 New York Times bestselling author of Young Forever and The UltraMind Solution
Major depression is one of the most common mental illnesses, affecting more than 21 million American adults and 3.7 million of our youth each year. And yet, the current one-size-fits-all medical model for psychiatric treatment of depression does not work for a significant portion of patients. Antidepressant medications are often treated as a magic bullet, but the truth is that depression is a complex mental and physical condition, influenced by nutrient intake and absorption, body chemistry, metabolism, genetics, hormones, food sensitivities, stressful life events, social support, and many other factors.
In Finally Hopeful, functional psychiatrist Dr. James Greenblatt offers a new model of treatment that acknowledges that depression is not "all in your head," but in your body. Dr. Greenblatt provides a unique guide to optimizing the nutrients, hormones, neurotransmitters, and many other biochemical factors that play a major role in most cases of depression. It is vital to address these physical factors using testing that customizes treatment to the individual, and Finally Hopeful outlines what tests you need; how to read the results for practical action; and how to work in conjunction with your physician. You'll also gain key insights into antidepressants and feel empowered in seeking the answers you deserve.
A functional psychiatry approach recognizes that depression has many causes and often requires a range of therapies, both drug and non-drug. Finally Hopeful makes the whole-body approach available to everyone, delivering real hope and relief.
*Includes a downloadable PDF of the Essential Functional Psychiatry Treatment Plan chart and the appendix from the book
“In this timely and transformative book, Dr. James Greenblatt boldly dismantles the outdated paradigm that seeks only to suppress symptoms with one-size-fits-all medications.”—David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain
“If you or someone you love struggles with depression, this book is essential reading.”—Mark Hyman, MD, #1 New York Times bestselling author of Young Forever and The UltraMind Solution
Major depression is one of the most common mental illnesses, affecting more than 21 million American adults and 3.7 million of our youth each year. And yet, the current one-size-fits-all medical model for psychiatric treatment of depression does not work for a significant portion of patients. Antidepressant medications are often treated as a magic bullet, but the truth is that depression is a complex mental and physical condition, influenced by nutrient intake and absorption, body chemistry, metabolism, genetics, hormones, food sensitivities, stressful life events, social support, and many other factors.
In Finally Hopeful, functional psychiatrist Dr. James Greenblatt offers a new model of treatment that acknowledges that depression is not "all in your head," but in your body. Dr. Greenblatt provides a unique guide to optimizing the nutrients, hormones, neurotransmitters, and many other biochemical factors that play a major role in most cases of depression. It is vital to address these physical factors using testing that customizes treatment to the individual, and Finally Hopeful outlines what tests you need; how to read the results for practical action; and how to work in conjunction with your physician. You'll also gain key insights into antidepressants and feel empowered in seeking the answers you deserve.
A functional psychiatry approach recognizes that depression has many causes and often requires a range of therapies, both drug and non-drug. Finally Hopeful makes the whole-body approach available to everyone, delivering real hope and relief.
*Includes a downloadable PDF of the Essential Functional Psychiatry Treatment Plan chart and the appendix from the book
A groundbreaking personalized model for psychiatric treatment of depression that helps readers identify their body's unique interplay of nutritional factors, biochemistry, lifestyle and genetics for effective and lasting care.
“In this timely and transformative book, Dr. James Greenblatt boldly ...
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About the author
A pioneer in the field of functional medicine, James M. Greenblatt, MD, has treated patients since 1988. He is the founder of Psychiatry Redefined, an educational platform to train clinicians in integrative and functional medicine for ADHD, and an assistant clinical professor of psychiatry at Tufts University School of Medicine and Dartmouth College Geisel School of Medicine. Dr. Greenblatt has lectured internationally on the scientific evidence for nutritional interventions in psychiatry and mental illness and is a leading contributor to helping physicians and patients understand the role of personalized medicine for mental illness. He is the author of eight books, including Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression.
Bill Gottlieb, CPHC, is one of America's most successful health book authors and journalists, and a certified professional health coach. He has authored and coauthored eighteen published books, which have sold over three million copies and been translated into 11 languages.
Bill Gottlieb, CPHC, is one of America's most successful health book authors and journalists, and a certified professional health coach. He has authored and coauthored eighteen published books, which have sold over three million copies and been translated into 11 languages.
A pioneer in the field of functional medicine, James M. Greenblatt, MD, has treated patients since 1988. He is the founder of Psychiatry Redefined, an educational platform to train clinicians in integrative and functional medicine for ADHD, and an assistant clinical professor of psychiatry at Tuf...
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